| 翻訳と辞書 |
| Ali Shilatifard ： ウィキペディア英語版 |
Ali Shilatifard
Ali Shilatifard (b. ''circa'' 1966 in Tehran, Iran) is an American biochemist/molecular biologist. He is considered a leader in the field of transcription and chromatin biology and leukemia research; and a pioneer in the field of epigenetics. Shilatifard is the Robert Francis Furchgott Professor and Chairman of the (Department of Biochemistry and Molecular Genetics at the Northwestern University Feinberg School of Medicine. ) He serves as a Senior Editor for the journal (''Science'' ), Deputy Editor for ''Science Advances'', and as an Editor for the journal ''Molecular and Cellular Biology'' and serves on the Board of Reviewing Editors for (''eLife'' ). (Shilatifard’s laboratory ) has contributed significantly to the molecular understanding of the cause of childhood leukemia through chromosomal translocations, the role of ELL in this process, and the discovery of the Super Elongation Complex as being a central complex linking MLL translocations into a diverse number of genes to leukemic pathogenesis. Shilatifard’s studies and contributions are (highly cited ) across many scientific fields. Shilatifard was recognized as a Jane Coffin Childs Fellow; recipient of the ASBMB-AMGEN Young Investigator Award; as a Scholar of the Leukemia and Lymphoma Society; and by the American Cancer Society. Shilatifard serves on the Scientific Advisory Boards of the Max Planck Society; (Genentech ); Cell Signaling Technology; and Keystone Symposia.
== Biography ==
Shilatifard developed his lifelong love of science as a young boy working with and observing his grandfather,〔(Ali Shilatifard: Discovering the roots of cancer, St. Louis Business Journal, Jul 23, 2006 )〕 a physician/scientist and Professor of Medicine of the University of Tehran. Shilatifard moved to the United States in 1984 where he began his study of organic chemistry at Kennesaw State University in Georgia. He began to work on his doctoral degree in biochemistry at the University of Georgia, Athens. Shilatifard completed and received his Ph.D. from the University of Oklahoma where his then mentor, Dr. Richard Cummings, had moved his program. As a Jane Coffin Childs Postdoctoral Fellow in the lab of Ron and Joan Conaway at the Oklahoma Medical Research Foundation, Shilatifard made a seminal contribution to the field of leukemia biology by identifying the first function of any of the MLL translocation partners found in leukemia 〔(Shilatifard et al, An RNA polymerase II elongation factor encoded by the human ELL gene, Science, Mar 29;271(5257):1873-6. (1996) )〕 and proposed that transcriptional elongation control is central to leukemia pathogenesis. Shilatifard began his independent lab in the (Edward A. Doisy Department of Biochemistry and Molecular Biology at the St. Louis University School of Medicine ), where he identified the first histone H3 lysine 4 (H3K4) methylase in ''Saccharomyces cerevisiae'': which he named Set1/COMPASS;〔Miller, T. et al. COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98, 12902-12907 (2001)〕〔Krogan, N. J. et al. COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277, 10753-10755, doi:10.1074/jbc.C200023200() (2002)〕 and defined the pathway of histone H3K4 methylation which is highly conserved from yeast to human.〔Smith, E. & Shilatifard, A. The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. Mol Cell 40, 689-701, doi:S1097-2765(10)00917-2 ()10.1016/j.molcel.2010.11.031 (2010)〕〔Lee, J. S. et al. Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Cell 131, 1084-1096, doi:S0092-8674(07)01350-5 ()10.1016/j.cell.2007.09.046 (2007)〕 Shilatifard has presented over 300 invited lectures at scientific meetings and universities in the U.S. and at international institutes and universities. Shilatifard moved his program to the (Stowers Institute for Medical Research ) where he was an Investigator from 2007-2014. Shilatifard left the Stowers Institute in 2014 to become the Robert Francis Furchgott Professor and Chairman of the Department of Biochemistry and Molecular Genetics of the
(Northwestern University Feinberg School of Medicine ). Ali Shilatifard is married to Laura Shilatifard with four children.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「Ali Shilatifard」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|